Choroidal blood flow and arterial blood pressure

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Regulation of choroidal blood flow during combined changes in intraocular pressure and arterial blood pressure.

PURPOSE To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). METHODS There were two study days in an open design. On the first day, OPP was varied by elevating IOP during a squatting-induced increase in MAP (28 subjects). On the second day, only t...

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Age-related impairment in choroidal blood flow compensation for arterial blood pressure fluctuation in pigeons.

PURPOSE Choroidal vessels compensate for changes in systemic blood pressure (BP) so that choroidal blood flow (ChBF) remains stable over a BP range of approximately 40 mm Hg above and below basal. Because of the presumed importance of ChBF regulation for maintenance of retinal health, we investigated if ChBF compensation for BP fluctuation in pigeons fails with age. METHODS Transcleral laser ...

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Choroidal blood flow in AMD.

In a recent article in this journal, Grunwald et al. 1 quantified foveolar choroidal blood flow using a Laser Doppler flowmeter in patients with nonexudative age-related macular degeneration (AMD). They found that choroidal blood volume and choroidal blood flow in patients with AMD were significantly reduced. However, they found no statistically significant difference for the choroidal blood ve...

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Nitric oxide and choroidal blood flow regulation.

PURPOSE Nitric oxide (NO) has been found to be an endothelial-derived relaxing factor mediating the vasodilatation that results from the stimulation of muscarinic endothelial receptors. It also has been identified as a putative neurotransmitter of parasympathetic origin in choroidal perivascular autonomic fibers. The authors investigated a potential role of NO in choroidal blood flow (ChBF) reg...

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Posture changes and subfoveal choroidal blood flow.

PURPOSE To evaluate the effect of posture change on subfoveal choroidal blood flow (ChBF) in normal volunteers. METHODS The pulsatile, nonpulsatile, and mean ChBF were measured with laser Doppler flowmetry in 11 healthy volunteers with a mean age of 32 +/- 13 (SD) years. The posture of the subjects was changed from standing (90 degrees ), to supine (-8 degrees ), and back to standing, with a ...

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ژورنال

عنوان ژورنال: Eye

سال: 2003

ISSN: 0950-222X,1476-5454

DOI: 10.1038/sj.eye.6700246